Targeting IL-4/IL-13 signaling to alleviate oral allergen–induced diarrhea
EB Brandt, A Munitz, T Orekov, MK Mingler… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Intestinal anaphylaxis (manifested by acute diarrhea) is dependent on IgE
and mast cells. OBJECTIVE: We aimed to define the respective roles of IL-4 and IL-13 and
their receptors in disease pathogenesis. METHODS: Wild-type mice and mice deficient in IL-
4, IL-13, and IL-13 receptor (IL-13R) α1 (part of the type 2 IL-4 receptor [IL-4R]) were
sensitized with ovalbumin (OVA)/aluminum potassium sulfate and subsequently given
repeated intragastric OVA exposures. The IL-4Rα chain was targeted with anti-IL-4Rα mAb …
and mast cells. OBJECTIVE: We aimed to define the respective roles of IL-4 and IL-13 and
their receptors in disease pathogenesis. METHODS: Wild-type mice and mice deficient in IL-
4, IL-13, and IL-13 receptor (IL-13R) α1 (part of the type 2 IL-4 receptor [IL-4R]) were
sensitized with ovalbumin (OVA)/aluminum potassium sulfate and subsequently given
repeated intragastric OVA exposures. The IL-4Rα chain was targeted with anti-IL-4Rα mAb …
