We have examined the metabolic fate of HDL cholesteryl ester (CE) delivered to cells
expressing scavenger receptor class B type I (SR-BI). Comparison of SR-BI with a related
class B scavenger receptor, CD36, showed a greater uptake and a more rapid and
extensive hydrolysis of HDL-CE when delivered by SR-BI. In addition, hydrolysis of HDL-CE
delivered by both receptors was via a neutral CE hydrolase. These data indicate that SR-BI,
but not CD36, can efficiently direct HDL-CE to a neutral CE hydrolytic pathway. In contrast …