Analysis of human parainfluenza virus 3 receptor binding variants: evidence for the use of a specific sialic acid-containing receptor
A Moscona, RW Peluso - Microbial pathogenesis, 1996 - Elsevier
In order for the fusion protein (F) of the human parainfluenza virus type 3 (HPF3) to promote
membrane fusion and viral entry, the haemagglutinin–neuraminidase (HN) glycoprotein
must interact with its receptor. Sialoglycoconjugates are known to be the receptors for the
HPF3 HN, however specific attachment factors or receptors for HPF3 have not been
identified. In this report we describe the analysis of variants of HPF3 with increased fusion-
promoting phenotypes that were selected by treatment with viral neuraminidase. The results …
membrane fusion and viral entry, the haemagglutinin–neuraminidase (HN) glycoprotein
must interact with its receptor. Sialoglycoconjugates are known to be the receptors for the
HPF3 HN, however specific attachment factors or receptors for HPF3 have not been
identified. In this report we describe the analysis of variants of HPF3 with increased fusion-
promoting phenotypes that were selected by treatment with viral neuraminidase. The results …