Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice
H Giese, WK Snyder, C Van Oostrom… - … /Genetic Toxicology and …, 2002 - Elsevier
Increased genomic instability has been found associated with cancer and aging. The p53
tumor suppressor protein is a major determinant of genomic instability as a regulator of cell
cycle control and apoptosis in response to DNA damage. To investigate the rate of age-
related mutation accumulation in the absence of p53, we crossed Trp53 null mice with
transgenic mice harboring a lacZ mutational target gene. In the hybrid animals, lacZ
mutation frequencies at early age (ie at about 2 months) were found to be the same as in the …
tumor suppressor protein is a major determinant of genomic instability as a regulator of cell
cycle control and apoptosis in response to DNA damage. To investigate the rate of age-
related mutation accumulation in the absence of p53, we crossed Trp53 null mice with
transgenic mice harboring a lacZ mutational target gene. In the hybrid animals, lacZ
mutation frequencies at early age (ie at about 2 months) were found to be the same as in the …
