Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1
TW Burke, JG Cook, M Asano, JR Nevins - Journal of Biological Chemistry, 2001 - ASBMB
The minichromosome maintenance (MCM) proteins, together with the origin recognition
complex (ORC) proteins and Cdc6, play an essential role in eukaryotic DNA replication
through the formation of a pre-replication complex at origins of replication. We used a yeast
two-hybrid screen to identify MCM2-interacting proteins. One of the proteins we identified is
identical to the ORC1-interacting protein termed HBO1. HBO1 belongs to the MYST family,
characterized by a highly conserved C 2 HC zinc finger and a putative histone …
complex (ORC) proteins and Cdc6, play an essential role in eukaryotic DNA replication
through the formation of a pre-replication complex at origins of replication. We used a yeast
two-hybrid screen to identify MCM2-interacting proteins. One of the proteins we identified is
identical to the ORC1-interacting protein termed HBO1. HBO1 belongs to the MYST family,
characterized by a highly conserved C 2 HC zinc finger and a putative histone …
