[HTML][HTML] Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation
MS Yan, PJ Turgeon, HSJ Man, MK Dubinsky… - Journal of Biological …, 2018 - ASBMB
Although the functional role of chromatin marks at promoters in mediating cell-restricted
gene expression has been well characterized, the role of intragenic chromatin marks is not
well understood, especially in endothelial cell (EC) gene expression. Here, we
characterized the histone H3 and H4 acetylation profiles of 19 genes with EC-enriched
expression via locus-wide chromatin immunoprecipitation followed by ultra-high–resolution
(5 bp) tiling array analysis in ECs versus non-ECs throughout their genomic loci. Importantly …
gene expression has been well characterized, the role of intragenic chromatin marks is not
well understood, especially in endothelial cell (EC) gene expression. Here, we
characterized the histone H3 and H4 acetylation profiles of 19 genes with EC-enriched
expression via locus-wide chromatin immunoprecipitation followed by ultra-high–resolution
(5 bp) tiling array analysis in ECs versus non-ECs throughout their genomic loci. Importantly …
