Heme oxygenase 1 in regulation of inflammation and oxidative damage
Publisher Summary Heine oxygenase-1 (HO-1) and HO-2 are cytoprotective enzymes that
degrade heme (a potent oxidant) to generate carbon monoxide (CO, a vasodilatory gas that
has anti-inflammatory properties), bilirubin (an antioxidant derived from biliverdin), and iron
(sequestered by ferritin). This chapter focuses on HO-1, the inducible isoform that is
upregulated by oxidative stress. Because of properties of HO-1 and its products, it is
believed that HO-1 may play an important role in protecting cells and tissues in the settings …
degrade heme (a potent oxidant) to generate carbon monoxide (CO, a vasodilatory gas that
has anti-inflammatory properties), bilirubin (an antioxidant derived from biliverdin), and iron
(sequestered by ferritin). This chapter focuses on HO-1, the inducible isoform that is
upregulated by oxidative stress. Because of properties of HO-1 and its products, it is
believed that HO-1 may play an important role in protecting cells and tissues in the settings …
