The role of costimulatory pathways in transplant tolerance
M Uehara, MM McGrath - Clinics in laboratory medicine, 2019 - labmed.theclinics.com
More than 37,000 patients underwent solid organ transplantation in the United States in
2017. A life-saving procedure, transplantation carries with it the need for lifelong
immunosuppression to prevent rejection. The most common cause of late allograft loss
remains chronic rejection. 1, 2 Also, immunosuppressive drugs, such as tacrolimus,
mycophenolic acid, and steroids, have significant side effects, which contribute to morbidity
and mortality post-transplantation. 3, 4 Thus, success in the field of transplantation is limited …
2017. A life-saving procedure, transplantation carries with it the need for lifelong
immunosuppression to prevent rejection. The most common cause of late allograft loss
remains chronic rejection. 1, 2 Also, immunosuppressive drugs, such as tacrolimus,
mycophenolic acid, and steroids, have significant side effects, which contribute to morbidity
and mortality post-transplantation. 3, 4 Thus, success in the field of transplantation is limited …
