Sphingosine 1-phosphate receptor 3–deficient dendritic cells modulate splenic responses to ischemia-reperfusion injury
A Bajwa, L Huang, E Kurmaeva… - Journal of the …, 2016 - journals.lww.com
The plasticity of dendritic cells (DCs) permits phenotypic modulation ex vivo by gene
expression or pharmacologic agents, and these modified DCs can exert therapeutic
immunosuppressive effects in vivo through direct interactions with T cells, either inducing T
regulatory cells (T REG s) or causing anergy. Sphingosine 1-phosphate (S1P) is a
sphingolipid and the natural ligand for five G protein–coupled receptors (S1P1, S1P2, S1P3,
S1P4, and S1P5), and S1PR agonists reduce kidney ischemia-reperfusion injury (IRI) in …
expression or pharmacologic agents, and these modified DCs can exert therapeutic
immunosuppressive effects in vivo through direct interactions with T cells, either inducing T
regulatory cells (T REG s) or causing anergy. Sphingosine 1-phosphate (S1P) is a
sphingolipid and the natural ligand for five G protein–coupled receptors (S1P1, S1P2, S1P3,
S1P4, and S1P5), and S1PR agonists reduce kidney ischemia-reperfusion injury (IRI) in …
