[HTML][HTML] Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36
Cardiac triacylglycerol (TAG) stores buffer the intracellular availability of long chain fatty acid
(LCFA) that act as nuclear receptor ligands, substrate for lipotoxic derivatives, and high
energy-yield fuel. The kinetic characteristics of TAG turnover and homeostatic mechanisms
linking uptake and storage dynamics in hearts have until now remained elusive. This work
examines TAG pool dynamics in the intact beating heart, under normal conditions and in
response to acute gene expression-induced changes in CD36. Dynamic mode 13 C NMR …
(LCFA) that act as nuclear receptor ligands, substrate for lipotoxic derivatives, and high
energy-yield fuel. The kinetic characteristics of TAG turnover and homeostatic mechanisms
linking uptake and storage dynamics in hearts have until now remained elusive. This work
examines TAG pool dynamics in the intact beating heart, under normal conditions and in
response to acute gene expression-induced changes in CD36. Dynamic mode 13 C NMR …