Lipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate
many aspects of cell physiology. However, our understanding of the biogenesis of LDs
remains very limited. Originating from the endoplasmic reticulum (ER), LDs are highly
unique organelles in that each LD is bounded by a monolayer of amphipathic lipids. Recent
progress has unveiled critical roles of non-bilayer lipids in LD formation. For instance, non-
bilayer lipids such as lysophospholipids, diacylglycerol and phosphatidic acid (PA) can …