[HTML][HTML] Molecular phenotype of kidney transplant indication biopsies with inflammation in scarred areas
PF Halloran, A Matas, BL Kasiske… - American Journal of …, 2019 - Elsevier
In kidney transplant biopsies, inflammation in areas of atrophy-fibrosis (i-IFTA) is associated
with increased risk of failure, presumably because inflammation is evoked by recent
parenchymal injury from rejection or other insults, but some cases also have rejection. The
present study explored the frequency of rejection in i-IFTA, by using histology Banff 2015
and a microarray-based molecular diagnostic system (MMDx). In unselected indication
biopsies (108 i-IFTA, 73 uninflamed IFTA [i0-IFTA], and 53 no IFTA), i-IFTA biopsies occurred …
with increased risk of failure, presumably because inflammation is evoked by recent
parenchymal injury from rejection or other insults, but some cases also have rejection. The
present study explored the frequency of rejection in i-IFTA, by using histology Banff 2015
and a microarray-based molecular diagnostic system (MMDx). In unselected indication
biopsies (108 i-IFTA, 73 uninflamed IFTA [i0-IFTA], and 53 no IFTA), i-IFTA biopsies occurred …
