Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the …
KA Dooley, S Millinder, TF Osborne - Journal of Biological Chemistry, 1998 - ASBMB
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in
the pathway for endogenous cholesterol synthesis, is a target for negative feedback
regulation by cholesterol. The promoter for HMG-CoA synthase contains two binding sites
for the sterol regulatory element-binding proteins (SREBPs). When cellular sterol levels are
low, the SREBPs are released from the endoplasmic reticulum membrane, allowing them to
translocate to the nucleus and activate SREBP target genes. In all SREBP-regulated …
the pathway for endogenous cholesterol synthesis, is a target for negative feedback
regulation by cholesterol. The promoter for HMG-CoA synthase contains two binding sites
for the sterol regulatory element-binding proteins (SREBPs). When cellular sterol levels are
low, the SREBPs are released from the endoplasmic reticulum membrane, allowing them to
translocate to the nucleus and activate SREBP target genes. In all SREBP-regulated …
