SPARC is over-expressed in adipose tissues of diet-induced obese rats and causes insulin resistance in 3T3-L1 adipocytes
Y Shen, Y Zhao, L Yuan, W Yi, R Zhao, Q Yi, T Yong - Acta histochemica, 2014 - Elsevier
Secreted protein acidic and rich in cysteine (SPARC) is a secretory multifunctional
matricellular glycoprotein. High circulating levels of SPARC have been reported to be
associated with obesity and insulin resistance. The aim of the present study was to
investigate whether SPARC induces insulin resistance and mitochondrial dysfunction in
adipocytes. Our results showed that feeding high fat diet to rats for 12 weeks significantly
increased SPARC expression in adipose tissues at both mRNA and protein levels …
matricellular glycoprotein. High circulating levels of SPARC have been reported to be
associated with obesity and insulin resistance. The aim of the present study was to
investigate whether SPARC induces insulin resistance and mitochondrial dysfunction in
adipocytes. Our results showed that feeding high fat diet to rats for 12 weeks significantly
increased SPARC expression in adipose tissues at both mRNA and protein levels …