Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen,
accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac
failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are
unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as
well as collagen deposition; however it is unclear whether collagen accumulates in the
ageing Drosophila heart. This work examined collagen deposition and cardiac function in …