Pathogenesis and treatment of refractory disease courses in systemic juvenile idiopathic arthritis: refractory arthritis, recurrent macrophage activation syndrome and …
R Erkens, Y Esteban, C Towe… - Rheumatic Disease …, 2021 - rheumatic.theclinics.com
Systemic juvenile idiopathic arthritis (sJIA) is generally seen as the most severe category of
JIA. These categories are distinct in their pathobiology, disease course and specific
comorbidities. Systemic JIA can manifest varying degrees of arthritis, but is distinct from
other JIA categories because of its prominent systemic features reflecting autoinflammation.
1 The introduction of biologic therapies in the past 20 years has revolutionized treatment
and improved outcomes for all children with JIA, but especially for sJIA with the approval of …
JIA. These categories are distinct in their pathobiology, disease course and specific
comorbidities. Systemic JIA can manifest varying degrees of arthritis, but is distinct from
other JIA categories because of its prominent systemic features reflecting autoinflammation.
1 The introduction of biologic therapies in the past 20 years has revolutionized treatment
and improved outcomes for all children with JIA, but especially for sJIA with the approval of …