[HTML][HTML] Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
S Prasad, R Mingrino, K Kaukinen, KL Hayes… - Laboratory …, 2005 - Elsevier
Claudin proteins comprise a recently described family of tight junction proteins that
differentially regulate paracellular permeability. Since other tight junction proteins show
alterations in distribution or expression in inflammatory bowel disease (IBD) we assessed
expression of claudins (CL) 2, 3 and 4 in IBD. CL 2 was strongly expressed along the
inflamed crypt epithelium, whilst absent or barely detectable in normal colon. In contrast, CL
3 and 4 were present throughout normal colonic epithelium and were reduced or …
differentially regulate paracellular permeability. Since other tight junction proteins show
alterations in distribution or expression in inflammatory bowel disease (IBD) we assessed
expression of claudins (CL) 2, 3 and 4 in IBD. CL 2 was strongly expressed along the
inflamed crypt epithelium, whilst absent or barely detectable in normal colon. In contrast, CL
3 and 4 were present throughout normal colonic epithelium and were reduced or …