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Clinical Medicine
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Protecting kidney from fibrosis by enhancing fatty acid oxidation
In this episode, Santiago Lamas and Verónica Miguel explain that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD...
Published March 1, 2021
Author's Take
Targeting a Braf/Mapk pathway in CoQ-deficiency kidney disease
In this episode, Ana Greka and Eriene-Heidi Sidhom explain that an investigation of cell-specific disease mechanisms in rare genetic disorder revealed Braf/Mapk as a candidate pathway for the treatment of kidney diseases...
Published March 1, 2021
Author's Take
The COVID-19 immune landscape correlation with disease severity
In this episode, Jane Buckner explains a longitudinal analysis of acute COVID-19 ranging from mild to severe disease determining immune trajectories of recovery...
Published February 1, 2021
Author's Take
Variant increases ER chaperones GRP78 and GRP94 and protects against liver injury
In this episode, Richard Austin, Paul Lebeau, and Michel Chrétien explain that the human Q152H ProPCSK9 mutation acquires an unexpected novel function: protection against ER stress and liver injury by enhancing chaperone expression...
Published January 19, 2021
Author's Take
Increased atrial fibrillation in diabetic mice by distinct mechanisms
In this episode, Olurotimi O. Mesubi explains that the discovery of oxidation of CaMKII and O-GlcNAcylation differentially increased atrial fibrillation risk in type 1 and type 2 diabetic mice...
Published January 19, 2021
Author's Take
mTOR-dependent translation amplifies microglia priming
In this episode, Melania Capasso explains how mTOR is hyperactivated in microglia with age and causes increased translation of inflammatory mediators, thus critically regulating microglia priming...
Published January 4, 2021
Author's Take
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
Persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes...
Published November 16, 2020
Author's Take
Germ cell tumors and other malignancies evolve from a shared precursor
In this episode, Justin Taylor and colleagues identify the genomic characteristics and clonal origins of a unique and aggressive clinical syndrome involving clonally related hematologic malignancies and germ cell tumors...
Published November 16, 2020
Author's Take
Kisspeptin receptor agonist and female reproductive disorders
In this episode, Ali Abbara and colleagues discuss that the Kisspeptin receptor agonist, MVT-602, has greater potency and longer duration of action than native kisspeptin-54, and thus increased therapeutic potential to treat female reproductive...
Published November 16, 2020
Author's Take
Maintenance DNA methylation is essential for development and stability
In this episode, Benjamin Singer and colleagues explain that maintenance DNA methylation at inflammatory gene loci is necessary to stabilize regulatory T cell identity and suppressive function during both development and lineage self-renewal...
Published November 9, 2020
Author's Take
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