Lucy Shapiro, of Stanford University, is a renowned molecular and developmental biologist whose work has answered the fundamental questions underlying the genetic and molecular decision-making process that directs an asymmetric cell division yielding daughter cells with different cell fates. Shapiro’s insights helped launch the field of systems biology, and more recently, her work has led to the development of novel antifungal drugs.
JCI Editor at Large Ushma S. Neill provides updated advice on generating a scientific manuscript with maximum impact.
In this episode, Tamás Röszer and colleagues demonstrate that breast-milk-derived alkylglycerols preserve beige adipocytes to protect against obesity.
JCI Editor at Large Ushma S. Neill interviews the geneticist, innovator, and entrepreneur George Church, of Harvard and MIT. Dr. Church developed the methods for the first genome sequencing, and his subsequent work has brought down the price of sequencing over 10-million-fold. His was one of the two research groups that first got CRISPR/Cas9 to work for precise gene editing in human cells by a homologous recombination, and he has been behind countless other scientific innovations and disruptions, specifically in the world of precision genome sequencing.
The transcription factor GATA-2 is critical regulator of hematopoietic stem and progenitor cell (HSPC) development and function, and mutations in the enhancer region of GATA2 are linked to blood disorders. In this episode, Emery Bresnick and colleagues develop and characterize a mouse model that harbors a human disease-associated GATA2 enhancer mutation. In this model, hematopoietic development and function were normal unless the animals were exposed to a secondary stress that necessitated blood cell regeneration. The results of this study provide important insight into GATA-2-dependent pathogenesis.